Pirfenex 200 mg (Pirfenidone)

Pirfenex 200 mg capsules contain 267mg of pirfenidone, a medication prescribed to treat idiopathic pulmonary fibrosis (IPF). Pirfenidone reduces growth factors, inhibits inflammatory cells, and modulates the immune response to slow down IPF progression.

Taking Pirfenex 200 mg as directed can alleviate respiratory symptoms, improve lung function, and reduce the risk of acute exacerbations. Proper dosage and administration are crucial for optimal results.

Pirfenidone benefits, potential interactions, and storage guidelines are essential to maximize its effectiveness and minimize potential side effects.

Main Points

? Pirfenex 200 mg is an oral capsule formulation containing 267mg of pirfenidone per capsule, used to treat idiopathic pulmonary fibrosis (IPF).? It reduces scar tissue formation, inhibits inflammatory cells, and modulates the immune response to slow down IPF progression.? The recommended dosing regimen should be followed for optimal results, taking the capsule orally with food and maintaining a consistent dosing schedule.? Pirfenex 200 mg can interact with medications such as warfarin, fluvoxamine, and rifampicin, requiring close monitoring and potential dosage adjustments.? Overdosage may cause gastrointestinal, neurological, respiratory, and cardiovascular complications, requiring immediate medical attention and supportive care.

What Is Pirfenex 200 mg?

Pirfenex 200 mg is a prescription medication containing pirfenidone, an anti-fibrotic drug that targets idiopathic pulmonary fibrosis (IPF).

Pirfenex 200 mg is an oral capsule formulation for oral administration. Each capsule contains 267mg of pirfenidone, equivalent to 200 mg of the active moiety. Inactive ingredients include lactose monohydrate, croscarmellose sodium, and magnesium stearate.

The white, opaque capsules are marked with ‘Pirfenex 200 mg‘ on the body and ‘200’ on the cap.

To achieve the best possible outcomes, patients must follow the prescribed dosage and administration instructions carefully.

How Pirfenex 200 mg Works

Pirfenex 200 mg works by reducing growth factors that stimulate scar tissue formation in the lungs, slowing down the progression of idiopathic pulmonary fibrosis (IPF).

The mechanism of action of pirfenidone, the active ingredient in Pirfenex 200 mg, involves three key steps:

This slows down IPF progression by reducing scarring in the lungs.

Uses of Pirfenidone

Pirfenidone is a treatment option for idiopathic pulmonary fibrosis (IPF). It slows down the progression of the disease.

Specifically, pirfenidone:

1. Reduces decline in lung function: Pirfenidone slows down the rate of decline in lung function.
2. Alleviates respiratory symptoms: Pirfenidone alleviates symptoms such as cough, fatigue, and shortness of breath.
3. Reduces exacerbations: By slowing down disease progression, pirfenidone reduces the frequency and severity of IPF exacerbations.
4. Improves survival rates: Studies have shown that pirfenidone treatment is associated with improved survival rates in IPF patients.

Benefits of Pirfenex 200 mg

Pirfenex 200 mg slows the progression of idiopathic pulmonary fibrosis (IPF), leading to improved lung function and easier breathing. This enables individuals to engage in daily activities with more energy.

The medication reduces the risk of acute exacerbations, which can be life-threatening for IPF patients. This decreases the likelihood of hospitalization and improves overall well-being.

Pirfenex 200 mg has anti-inflammatory and anti-fibrotic properties, reducing inflammation and scarring in the lungs. This leads to improved exercise tolerance and overall quality of life.

Dosage and Administration

When taking Pirfenex 200 mg, follow the recommended dosing regimen for optimal results. Understand the administration methods, including timing and frequency of doses, to ensure effective treatment. Review and follow guidelines for your specific condition to minimize potential side effects and maximize benefits.

Dosing Regimens

Pirfenex 200 mg Dosing Regimen for Idiopathic Pulmonary Fibrosis (IPF) Treatment:

The recommended dosing regimen for Pirfenex 200 mg is as follows:

Initial Dosing: 267mg (three 89mg capsules) orally, three times a day, for a total daily dose of 801 mg.

Titration: After 7-10 days of initial dosing, increase the dose to 534 mg (six 89mg capsules) orally, three times a day, for a total daily dose of 1602 mg.

Maintenance Dosing: Continue the dose of 534 mg orally, three times a day, for a total daily dose of 1602 mg, as long as the treatment is deemed effective and tolerated.

Dose Adjustment: Reduce the dose or temporarily discontinue treatment if adverse effects occur, such as gastrointestinal upset, skin rash, or photosensitivity reactions.

Administration Methods

Take Pirfenex 200 mg orally with food to minimize gastrointestinal upset. Swallow the capsules whole without crushing or chewing. This administration method reduces the risk of stomach irritation and ensures optimal absorption of the medication. Maintain a consistent dosing schedule, taking the capsules at the same time every day, ideally with a meal. If a dose is missed, take it as soon as possible. If it’s close to the next scheduled dose, skip the missed dose and continue with the regular schedule. Do not take extra doses to compensate. If unsure about the dosing regimen or experiencing unusual symptoms, consult a healthcare provider for personalized guidance and support.

Pirfenex 200 mg Side Effects

Pirfenex 200 mg can cause gastrointestinal disturbances, including nausea, vomiting, and diarrhea. These symptoms are usually mild and temporary, but persisting or worsening symptoms should be reported to a doctor.

Additional possible side effects include:

1. Fatigue: Feeling tired or weak.
2. Headache: Mild to moderate headaches, manageable with over-the-counter pain relievers.
3. Rash: Mild skin rashes or itching, treatable with topical creams or ointments.
4. Elevated liver enzymes: Temporary increases in liver enzyme levels, monitored through regular blood tests.

It is essential to report any side effects to a doctor, as they can adjust the dosage or recommend alternative treatments.

Precautions and Contraindications

When considering Pirfenex 200 mg, be aware of the following precautions and contraindications. Pregnant or breastfeeding women should exercise caution, as the effects on the baby are not fully understood. If you have a history of allergic reactions to similar medications, discuss these concerns with your doctor before starting treatment.

Pregnancy and Lactation

Pirfenidone therapy during pregnancy and lactation requires careful consideration due to limited data on potential risks and benefits.

When it comes to pregnancy, the following considerations are essential:

1. Reproductive toxicity: Animal studies have shown pirfenidone to have reproductive toxicity, which may indicate a risk to human fetal development.
2. Fetal growth restriction: There is a risk of fetal growth restriction, which could lead to adverse outcomes for the fetus.
3. Maternal health: Pirfenex 200 mg may exacerbate underlying maternal health conditions, which could negatively impact the pregnancy.
4. Lactation risks: It is unknown whether pirfenidone is excreted in human milk, and the potential risks to the infant are unclear.

Careful evaluation of the benefits and risks of Pirfenex 200 mg therapy in pregnant or lactating women is necessary, and alternative treatment options should be considered if necessary.

Allergic Reactions

Initiating Pirfenex 200 mg therapy requires awareness of potential allergic reactions. Monitor yourself closely for signs of an allergic reaction, such as hives, itching, swelling, or difficulty breathing. If you experience any of these symptoms, seek medical attention immediately.

Previous hypersensitivity reactions to Pirfenidone or its excipients increase the risk of an allergic reaction. A history of allergies or asthma also increases this risk.

If you’re unsure about your allergy status or have concerns, consult your doctor before starting Pirfenex 200 mg. They will assess your medical history and determine the best course of action. Prioritizing safety and taking proactive steps minimizes the risk of an allergic reaction.

Drug Interactions With Pirfenidone

Pirfenidone Interactions with Other Medications

Co-administering pirfenidone with certain medications can alter its pharmacokinetics and efficacy. Pirfenidone is a substrate of cytochrome P450 (CYP) enzymes, which can lead to interactions with medications that inhibit or induce these enzymes.

Specific drug interactions to be aware of include:

1. Antacids: Taking pirfenidone with antacids containing aluminum, magnesium, or calcium can reduce its absorption. Administer pirfenidone at least 2 hours before or after taking antacids.

2. Warfarin: Co-administration with warfarin may increase the risk of bleeding. INR monitoring may be required more frequently.

3. CYP1A2 inhibitors and inducers: Inhibitors like fluvoxamine can increase pirfenidone exposure, while inducers like rifampicin can decrease it. Dosage adjustments may be necessary.

4. Other medications: Pirfenidone may interact with medications like digoxin, which are substrates of P-glycoprotein or breast cancer resistance protein (BCRP). Close monitoring is required.

Disclose all medications to your doctor to ensure safe and effective treatment with pirfenidone.

Pirfenex 200 mg Overdosage

Pirfenex 200 mg overdose symptoms include gastrointestinal disturbances, fatigue, and respiratory issues. If an overdose is suspected, immediate medical attention is necessary. Treatment options may involve supportive care, activated charcoal administration, and close monitoring.

Symptoms of Overdose

Symptoms of Overdose

Taking more than the recommended dose of Pirfenex 200 mg can cause a range of symptoms that require immediate medical attention.

Common symptoms of Pirfenex 200 mg overdose include:

1. Gastrointestinal disturbances: Nausea, vomiting, diarrhea, and abdominal pain. Untreated, these symptoms can lead to dehydration and electrolyte imbalance.

2. Neurological disturbances: Dizziness, headache, and fatigue. In severe cases, seizures, tremors, or loss of consciousness may occur.

3. Respiratory complications: Overdose can cause respiratory depression, characterized by slow breathing rates, shallow breaths, and bluish discoloration of the skin and lips.

4. Cardiovascular issues: Rapid heartbeat, palpitations, or even cardiac arrest may occur in severe cases of overdose.

Immediate medical attention is essential if you or someone you know has overdosed on Pirfenex 200 mg. Prompt treatment reduces the risk of severe complications and long-term damage.

Treatment Options Available

Pirfenex 200 mg overdose treatment typically involves a combination of supportive care and medication to alleviate symptoms and prevent complications. Healthcare providers closely monitor vital signs, including heart rate, blood pressure, and oxygen saturation, and perform diagnostic tests like electrocardiograms or blood tests to assess the severity of the overdose.

Supportive care may include administering oxygen therapy, fluid replacement, or medication to manage symptoms like nausea, vomiting, or seizures. In severe cases, mechanical ventilation or other life-supporting interventions may be required. Activated charcoal may be given to absorb the drug and reduce its absorption into the bloodstream.

Medications like anti-nausea drugs, anticonvulsants, or antidepressants may be prescribed to alleviate specific symptoms. In some cases, gastric lavage or whole-bowel irrigation may be recommended to remove the drug from the system. It is crucial to follow healthcare providers’ instructions and attend follow-up appointments to ensure a full recovery.

Storage and Handling

Storage and Handling

Store Pirfenex 200 mg in its original packaging, protected from light, and out of reach of children. Proper storage maintains the medication’s potency and ensures safety. When handling Pirfenex 200 mg:

1. Store away from moisture: Avoid humid environments like bathrooms or kitchens.
2. Maintain a consistent temperature: Store at room temperature (15?C to 30?C or 59?F to 86?F).
3. Avoid direct sunlight: Store in a dark or shaded area.
4. Check expiration dates: Regularly inspect supplies for expired or damaged packets and dispose of them according to local regulations.

Availability and Cost

Pirfenex 200 mg is available at authorized pharmacies, hospitals, and online retailers. Prices vary depending on location and availability. In the United States, the average wholesale price for a 200 mg capsule is $20-$30. However, prices can range from $15 to $50 per capsule, depending on the vendor and insurance coverage.

Outside the United States, prices may differ due to varying pricing regulations and healthcare systems. Verify the cost with your healthcare provider, pharmacist, or insurance provider. Discounts, coupons, or patient assistance programs may be available to reduce the cost.

Frequently Asked Questions

Can Pirfenex 200 mg Be Used to Treat Other Lung Diseases?

Pirfenex 200 mg, primarily approved for idiopathic pulmonary fibrosis, may also benefit patients with other interstitial lung diseases, such as chronic hypersensitivity pneumonitis, according to research.

Is Pirfenex 200 mg Available in Different Strengths or Forms?

Pirfenex 200 mg is available in different forms, including tablets, capsules, and oral solutions, catering to individual patient needs.

Can I Take Pirfenex 200 mg During Pregnancy or Breastfeeding?

Pirfenex 200 mg should only be taken during pregnancy or breastfeeding under the guidance of a doctor, as the potential risks to the fetus or baby are unknown and require a careful consideration of benefits versus potential harm.

How Long Does It Take to See the Effects of Pirfenex 200 mg?

Pirfenex 200 mg effects typically become apparent within 6-12 weeks, as the body adjusts to the medication and inflammation subsides, leading to improved lung function and symptom relief.

Can I Stop Taking Pirfenex 200 mg if I Feel Better?

Stopping Pirfenex 200 mg treatment without consulting a doctor is not recommended, even if symptoms have improved. Abruptly discontinuing medication can lead to relapse or withdrawal symptoms, undermining progress made. Consult a doctor before altering treatment.

Conclusion

Pirfenex 200 mg (Pirfenidone) is prescribed to treat idiopathic pulmonary fibrosis. Studies have shown that it slows disease progression and reduces mortality risk. To manage symptoms and improve quality of life, take Pirfenex 200 mg as directed. Follow dosage instructions carefully and report any concerns or side effects to your doctor. Pirfenex 200 mg can help slow disease progression when used properly.